4^th Mar 2025

Polynucleotides vs. Exosomes: Which Skin & Hair Treatment is Best?

If you’ve been researching regenerative treatments for skin and hair restoration, you’ve likely come across Polynucleotides. Known for their ability to hydrate, repair, and strengthen the skin, Polynucleotide injections have gained popularity in aesthetic medicine. However, the next evolution in skin and hair rejuvenation has arrived—Exosomes.

At Fiji Skin Clinic, we exclusively offer Exosome Therapy because it outperforms Polynucleotides in every way. Exosomes deliver deeper cellular repair, faster results, and more powerful regeneration for youthful, radiant skin and stronger hair regrowth.

Let’s break down the key differences between Polynucleotides and Exosomes—and why Exosomes are the ultimate game-changer in skin and hair restoration.

What are Polynucleotides?

Polynucleotides are DNA fragments derived from salmon, trout or other sources, known for their ability to:

Boost skin hydration

Improve elasticity and repair damaged skin

Reduce inflammation and promote healing

Polynucleotides work by stimulating fibroblasts—the cells responsible for producing collagen and elastin. This makes them a good option for those with dry, sensitive, or damaged skin.

However, while Polynucleotides help strengthen and hydrate, they don’t have the deep regenerative power needed to reverse skin ageing, boost collagen dramatically, or regrow hair at a cellular level.

Why Exosomes Are More Advanced Than Polynucleotides

Exosomes represent the future of regenerative medicine. They are 1000x more powerful than traditional treatments like PRP and Polynucleotides, delivering a higher concentration of growth factors, proteins, and regenerative signals directly to the skin and scalp.

Unlike Polynucleotides, which primarily hydrate and repair, Exosomes go deeper, triggering profound skin renewal, collagen production, and hair follicle regeneration.

Exosomes vs. Polynucleotides: Which One is Better?

Feature	Polynucleotides	Exosomes
Hydration & Repair	Yes	Yes (plus deep healing)
Collagen Stimulation	Mild	Intense
Regenerates Skin Cells	Limited	Full cellular renewal
Reduces Wrinkles & Pigmentation	Mild	Dramatic improvement
Hair Follicle Regrowth	No	Thickens & strengthens hair
Speed of Results	Slow (4–6 weeks)	Fast (visible in weeks)
Longevity of Results	Moderate	Long-lasting

 

Exosomes work at the deepest cellular level, unlike Polynucleotides, which only provide surface-level improvements. That’s why they’re the most advanced treatment available for skin and hair rejuvenation.

Exosomes with CO₂  at Fiji Skin Clinic, Birmingham

What makes our Exosome treatment even more effective is how we deliver it. Most clinics apply Exosomes topically after microneedling, but at Fiji Skin Clinic, we take it a step further.

We use the TargetCool CO2 Gun to fire Exosomes deep into the skin immediately after microneedling.

This:

Enhances penetration for deeper absorption

Cools & soothes the skin, reducing inflammation

Speeds up healing, so you see results faster

This combination of Exosomes + CO2 + Microneedling ensures that every drop of regenerative power reaches the deeper layers of your skin and scalp, delivering the best possible outcome.

FAQ: Polynucleotides vs.Exosomes

1. Are Exosomes better than Polynucleotides for skin and hair?

Yes! Polynucleotides help with hydration and repair, but Exosomes go much further, actively regenerating skin cells and boosting collagen for younger, firmer skin.

2. Can Exosomes help with hair regrowth?

Polynucleotides help with hydration and skin strengthening, while Exosomes actively regenerate and repair skin DNA at a much deeper level, making them the most advanced option.

3. Does Exosome microneedling hurt?

No! At Fiji Skin Clinic, we use TargetCool Gun which uses CO2 to cool the skin and comfort. TargetCool Gun also delivers the Exosomes deep into the dermal layers of skin for optimal results whilst speeding up healing for faster results.

4. How soon will I see results?

Exosomes are ideal for skin rejuvenation, hair loss, anti-ageing, and deep cellular repair, making them perfect for those wanting visible, long-lasting improvements. Most clients see improvements in skin texture, elasticity, and radiance within weeks. For hair regrowth, visible thickening happens within a few months.

Ready to transform your skin & hair? 

Book your Exosome Consultation at Fiji Skin Clinic today and unlock the most advanced skin and hair restoration available in Birmingham.

Book a Consultation 

 

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